Immunoelectrophoresis - blood

定义

Serum immunoelectrophoresis is a lab test that measures proteins called immunoglobulins in the blood. Immunoglobulins are proteins that function as 抗体, which fight infection. There are many types of immunoglobulins that fight different types of infections. Some immunoglobulins can be abnormal and may be due to cancer.

Immunoglobulins can also be measured in the 尿液.

Alternative Names

IEP - serum; Immunoglobulin electrophoresis - blood; Gamma globulin electrophoresis; Serum immunoglobulin electrophoresis; 淀粉样变 - electrophoresis serum; 多发性骨髓瘤 - serum electrophoresis; Waldenström - serum electrophoresis

How the Test is Performed

A blood sample is needed.

How to Prepare for the Test

There is no special preparation for this test.

How the Test will Feel

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. This soon goes away.

Why the Test is Performed

This test is most often used to check the levels of 抗体 when certain cancers and other disorders are present or suspected.

正常的结果

A normal (negative) result means that the blood sample had normal types of immunoglobulins. The level of one immunoglobulin was not higher than any other.

What Abnormal Results Mean

Abnormal results may be due to:

• 淀粉样变 (buildup of abnormal proteins in tissues and organs)
• 白血病或 Waldenström macroglobulinemia (types of white blood cell cancers)
• Lymphoma (cancer of the lymph tissue)
• Monoclonal gammopathy of unknown significance (MGUS)
• 多发性骨髓瘤 (a type of blood cancer)
• 其他癌症
• 感染

风险

There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight, but may include:

• Excessive bleeding
• Fainting or feeling lightheaded
• Multiple punctures to locate veins
• Hematoma (blood accumulating under the skin)
• 感染 (a slight risk any time the skin is broken)

参考文献

Aoyagi K, Ashihara Y, Kasahara Y. Immunoassays and immunochemistry. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24日艾德. Philadelphia, PA: Elsevier; 2022:chap 45.

Park JY, Patel K. Immunochemical techniques. In: Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7日艾德. St Louis, MO: Elsevier; 2023:chap 26.